X-rays vs. carbon-ion tumor therapy: Cytogenetic damage in lymphocytes

Marco Durante, Shigeru Yamada, Koichi Ando, Yoshiya Furusawa, Tetsuya Kawata, Hideyuki Majima, Takashi Nakano, Hirohiko Tsujii

研究成果: Article査読

66 被引用数 (Scopus)


Purpose: To measure chromosomal aberrations in peripheral blood lymphocytes from cancer patients treated with X-rays or carbon ions (C-ions). Methods and Materials: Blood samples from patients diagnosed for esophageal or uterine cervical cancer were obtained before, during, and at the end of the radiation treatment. The novel technique of interphase chromosome painting was used to detect aberrations in prematurely condensed chromosomes 2 and 4. The fraction of aberrant lymphocytes was measured as a function of the dose to the tumor volume. For comparison, blood samples were also exposed in vitro to X-rays or to carbon ions accelerated at the HIMAC. Results: C- ions were more efficient than X-rays in the induction of chromosomal aberrations in vitro. In patients with similar pathologies, tumor positions, and radiation field sizes, however, C-ions induced a lower fraction of aberrant lymphocytes than X-rays during the treatment. The initial slope of the dose-response curve for the induction of chromosomal aberrations during the treatment was correlated to the relative decrease in the number of white blood cells and lymphocytes during the treatment. Conclusion: C-ions induce a lower level of cytogenetic damage in lymphocytes than X-rays, reducing the risk of bone marrow morbidity. (C) 2000 Elsevier Science Inc.

ジャーナルInternational Journal of Radiation Oncology Biology Physics
出版ステータスPublished - 2000 6月 1

ASJC Scopus subject areas

  • 放射線
  • 腫瘍学
  • 放射線学、核医学およびイメージング
  • 癌研究


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